Is the BCG Vaccine Safe for Undernourished Individuals?

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ID: 112416
2012
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Abstract
Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition. The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals. An experimental model of undernutrition was established by subjecting BALB/c mice to dietary restriction. These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined. A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver. In addition, only undernourished animals had bacteria in the lungs and thymus. Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-α, IFN-γ, and IL-10 was also diminished in these mice. Taken together, these results indicate that BCG infection is more severe in undernourished mice. Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.
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Authors Ishikawa, Larissa Lumi Watanabe;da Rosa, Larissa Camargo;França, Thais Graziela Donegá;Peres, Raphael Sanches;Chiuso-Minicucci, Fernanda;Zorzella-Pezavento, Sofia Fernanda Gonçalves;Sartori, Alexandrina;Ishikawa, Larissa Lumi Watanabe;da Rosa, Larissa Camargo;França, Thais Graziela Donegá;Peres, Raphael Sanches;Chiuso-Minicucci, Fernanda;Zorzella-Pezavento, Sofia Fernanda Gonçalves;Sartori, Alexandrina;
Journal clinical and developmental immunology
Year 2012
DOI
https://doi.org/10.1155/2012/673186
URL
https://dx.doi.org/10.1155%2F2012%2F673186
Keywords
vaccination National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Disease Models Animal Inbred BALB C feeding behavior malnutrition / complications cytokines / metabolism malnutrition / immunology* pmid:22567029 pmc3332168 doi:10.1155/2012/673186 larissa lumi watanabe ishikawa larissa camargo da rosa alexandrina sartori bcg vaccine / administration & dosage* bcg vaccine / adverse effects bacterial load tuberculosis / complications tuberculosis / immunology*

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