The Evolutionary Fate and Consequences of Duplicate Genes

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2000
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Abstract
Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolve new functions. Observations from the genomic databases for several eukaryotic species suggest that duplicate genes arise at a very high rate, on average 0.01 per gene per million years. Most duplicated genes experience a brief period of relaxed selection early in their history, with a moderate fraction of them evolving in an effectively neutral manner during this period. However, the vast majority of gene duplicates are silenced within a few million years, with the few survivors subsequently experiencing strong purifying selection. Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species.
Reference Key
lynch2000sciencethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael Lynch;John S. Conery;Michael Lynch;John S. Conery;
Journal Science
Year 2000
DOI
10.1126/science.290.5494.1151
URL
https://doi.org/10.1126%2Fscience.290.5494.1151
Keywords
Evolution databases National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice animals humans pubmed abstract nih national institutes of health national library of medicine models research support u.s. gov't P.H.S. Molecular* Genes Base Sequence mutation factual comment time factors probability oryza / genetics selection proteins / genetics genome* pmid:11073452 doi:10.1126/science.290.5494.1151 m lynch j s conery amino acid substitution arabidopsis / genetics caenorhabditis elegans / genetics chickens / genetics drosophila melanogaster / genetics gene duplication gene silencing duplicate* proteins / chemistry saccharomyces cerevisiae / genetics stochastic processes

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