Yersinia pestis--etiologic agent of plague.

Clicks: 155
ID: 112103
1997
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Abstract
Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to the wide range of mammalian hosts and their attendant fleas. The flea/rodent life cycle of Y. pestis, a gram-negative obligate pathogen, exposes it to very different environmental conditions and has resulted in some novel traits facilitating transmission and infection. Studies characterizing virulence determinants of Y. pestis have identified novel mechanisms for overcoming host defenses. Regulatory systems controlling the expression of some of these virulence factors have proven quite complex. These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague.
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perry1997clinicalyersinia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R D Perry;J D Fetherston;R D Perry;J D Fetherston;
Journal clinical microbiology reviews
Year 1997
DOI
10.1128/CMR.10.1.35
URL
http://dx.doi.org/10.1128/CMR.10.1.35
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