Hypertriglyceridemia in Diabetes Mellitus: Implications for Pediatric Care

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ID: 111982
2018
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Abstract
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). It is estimated that the risk of CVD in diabetes mellitus (DM) is 2 to 10 times higher than in the general population. Much of this increased risk is thought to be related to the development of an atherogenic lipid profile, in which hypertriglyceridemia is an essential component. Recent studies suggest that dyslipidemia may be present in children and adolescents with DM, particularly in T2DM and in association with poor control in T1DM. However, the role of hypertriglyceridemia in the development of future CVD in youth with DM is unclear, as data are scarce. In this review, we will evaluate the pathophysiology of atherogenic hypertriglyceridemia in DM, the evidence regarding an independent role of triglycerides in the development of CVD, and the treatment of hypertriglyceridemia in patients with DM, highlighting the potential relevance to children and the need for more data in children and adolescents to guide clinical practice.
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gidding2018journalhypertriglyceridemia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Md Jacob C Hartz,Md Sarah De Ferranti,Samuel S. Gidding;Md Jacob C Hartz;Md Sarah De Ferranti;Samuel S. Gidding;
Journal journal of the endocrine society
Year 2018
DOI
10.1210/js.2018-00079
URL
https://sciprofiles.com/publication/view/658063ed14b13c467c4953b4c389814f
Keywords
Children CVD diabetes mellitus adolescents treatment dyslipidemia hypertriglyceridemia

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