Impaired Humoral Response to Vaccines among HIV-Exposed Uninfected Infants

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ID: 111853
2011
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Abstract
Little is known about the vaccine protective response for infants born from HIV-infected mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine in vertically HIV-exposed uninfected infants and compared them to those of control infants not exposed to the virus. The quantitative determination of specific neutralizing antibodies against hepatitis B, diphtheria, and tetanus were performed blindly on serum samples. The results showed that 6.7% of the HIV-exposed uninfected individuals were nonresponders to hepatitis B vaccine (anti-HBs titer,
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Authors Beatriz Mariana Abramczuk;Taís Nitsch Mazzola;Yara Maria Franco Moreno;Tatiane Queiroz Zorzeto;Wagner Quintilio;Paulo Silva Wolf;Maria Heloisa Blotta;André Moreno Morcillo;Marcos Tadeu Nolasco da Silva;Maria Marluce dos Santos Vilela;Beatriz Mariana Abramczuk;Taís Nitsch Mazzola;Yara Maria Franco Moreno;Tatiane Queiroz Zorzeto;Wagner Quintilio;Paulo Silva Wolf;Maria Heloisa Blotta;André Moreno Morcillo;Marcos Tadeu Nolasco da Silva;Maria Marluce dos Santos Vilela;
Journal clinical and vaccine immunology
Year 2011
DOI
10.1128/CVI.05065-11
URL
https://doi.org/10.1128%2FCVI.05065-11
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't female male Infant newborn Antibodies hepatitis b / prevention & control immunization programs bacterial / blood* pmid:21775515 pmc3165213 doi:10.1128/cvi.05065-11 beatriz mariana abramczuk taís nitsch mazzola maria marluce dos santos vilela brazil diphtheria / immunology diphtheria / prevention & control diphtheria-tetanus-pertussis vaccine / administration & dosage diphtheria-tetanus-pertussis vaccine / immunology* hiv infections / complications hiv infections / immunology* hepatitis b / immunology hepatitis b antibodies / blood* hepatitis b vaccines / administration & dosage hepatitis b vaccines / immunology* tetanus / immunology tetanus / prevention & control

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