Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization
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ID: 111837
2020
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Abstract
Phosphorus (P) is an essential component for all living beings. Low P diets prompt phenotypic and molecular adaptations to maintain P homeostasis and increase P utilization (PU). Knowledge of the molecular mechanisms of PU is needed to enable targeted approaches to improve PU efficiency and thus lower P excretion in animal husbandry. In a previous population study, Japanese quail were subjected to a low P diet lacking mineral P and exogenous phytase. Individual PU was determined based on total P intake and excretion. A subset of 20 extreme siblings discordant for PU was selected to retrieve gene expression patterns of ileum (n = 10 per PU group). Sequencing reads have been successfully mapped to the current Coturnix japonica reference genome with an average mapping rate of 86%. In total, 640 genes were found to be differentially abundant between the low and high PU groups (false discovery rate ≤ 0.05). Transcriptional patterns suggest a link between improved PU and mitochondrial energy metabolism, accelerated cell proliferation of enterocytes, and gut integrity. In assessing indicators of the efficient use of macro- and micronutrients, further research on turnover and proliferation rates of intestinal cells could provide an approach to improve P efficiency in poultry species.
| Reference Key |
wimmers2020internationalileal
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| Authors | Michael Oster,Henry Reyer,Nares Trakooljul,Frank M. Weber,Lu Xi,Eduard Murani,S. Ponsuksili,Markus Rodehutscord,Jörn Bennewitz,Klaus Wimmers;Michael Oster;Henry Reyer;Nares Trakooljul;Frank M. Weber;Lu Xi;Eduard Murani;S. Ponsuksili;Markus Rodehutscord;Jörn Bennewitz;Klaus Wimmers; |
| Journal | International journal of molecular sciences |
| Year | 2020 |
| DOI |
10.3390/ijms21082762
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| URL | |
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