Prediction of Peptide Vascularization Inhibitory Activity in Tumor Tissue as a Possible Target for Cancer Treatment

Clicks: 271
ID: 111816
2019
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Abstract
The prediction of metabolic activities in silico form is crucial to be able to address all research possibilities without exceeding the experimental costs. In particular, for cancer research, the prediction of certain activities can be of great help in the discovery of different treatments. In this work it has been proposed to predict, through Machine Learning, the anti-angiogenic activity of peptides is currently being used in cancer treatment and is giving hopeful results. From a list of peptide sequences, three types of molecular descriptors were obtained (AAC, DC and TC) that offered the possibility of training different ML algorithms. After a Feature Selection process, different models were obtained with a predictive value that surpassed the current state of the art. These results shown that ML is useful for the classification and prediction of the activity of new peptides, making experimental screening cheaper and faster.
Reference Key
liñares-blanco2019proceedingsprediction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jose Liñares-Blanco;Carlos Fernandez-Lozano;Liñares-Blanco, Jose;Fernandez-Lozano, Carlos;
Journal proceedings
Year 2019
DOI
10.3390/proceedings2019021015
URL
https://doi.org/10.3390/proceedings2019021015
Keywords
Cancer Screening Machine learning peptides feature selection activity prediction Cancer Screening Machine learning peptides feature selection activity prediction

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