Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha

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ID: 111771
1999
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Abstract
Adipocyte differentiation is regulated by at least two major transcription factors, CCAAT/enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma). Expression of PPARgamma in fibroblasts converts them to fat-laden cells with an adipocyte-like morph …
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Authors El-Jack AK;Hamm JK;Pilch PF;Farmer SR;;
Journal The Journal of biological chemistry
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10075691##substances
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Adipocytes / metabolism enhancer elements genetic* pmid:10075691 doi:10.1074/jbc.274.12.7946 A K El-Jack J K Hamm S R Farmer 3T3 Cells Adipocytes / cytology Adipocytes / drug effects Biological Transport / drug effects CCAAT-Enhancer-Binding Proteins Cell Differentiation / drug effects DNA-Binding Proteins / metabolism* Fibroblasts / metabolism Glucose / metabolism* Glucose Transporter Type 4 Insulin / pharmacology* Inbred BALB C Monosaccharide Transport Proteins / metabolism Muscle Proteins* Nuclear Proteins / metabolism* Receptors Cytoplasmic and Nuclear / metabolism* Transcription Factors / metabolism*

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