A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector

Clicks: 215
ID: 111750
2008
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Abstract
A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.
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Authors Hongliang Huang;Hai Yu;Da Li;Yang Liu;Fenping Shen;Jun Zhou;Qingqing Wang;Guping Tang;Huang, Hongliang;Yu, Hai;Li, Da;Liu, Yang;Shen, Fenping;Zhou, Jun;Wang, Qingqing;Tang, Guping;
Journal International journal of molecular sciences
Year 2008
DOI
10.3390/ijms9112278
URL
https://www.mdpi.com/1422-0067/9/11/2278#citedby
Keywords
polyethylenimine 2-hydroxypropyl-α-cyclodextrin non-viral gene delivery vector co-polymer polyethylenimine 2-hydroxypropyl-α-cyclodextrin non-viral gene delivery vector co-polymer

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