An insight into crystallization test: A neoteric approach for screening premalignant and malignant lesions

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ID: 111291
2020
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Abstract
Introduction: Crystallization test is based on the principle that, when a salt crystallizes out of an aqueous solution, the crystal growth is influenced by the presence of other substances in the solution, such as blood or plant extracts. If a mixture of copper chloride solution with a small amount of whole blood is allowed to crystallize under controlled experimental conditions, an aggregate of crystals forms. Crystallization method can be used as a diagnostic aid to provide information about the systemic conditions and general health of the patient. Aim: This study aims to study the patterns of crystallization and to further determine the efficacy of crystallization test as a screening modality in premalignant lesions and oral squamous cell carcinoma (OSCC). Materials and Methods: Fifty patients of OSCC, 50 patients of premalignant lesions, and 50 healthy individuals were selected. One drop of blood was collected from the study groups to perform crystallization using cupric chloride. Statistical Analysis Used: Statistical analysis was performed using Chi-square test, Student's t-test (two-tailed), and analysis of variance. Results: The different patterns of crystals formed were studied and statistically analyzed. Conclusion:Based on the study, it was concluded that Crystallization test can be used as an effective screening modality for detection of premalignant lesions and OSCC.
Reference Key
rawat2020journalan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rawat;Garima Rawat;Kirti Kureel;Aadithya B Urs;
Journal journal of cancer research and therapeutics
Year 2020
DOI
0973-1482
URL
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=440;epage=444;aulast=Rawat;type=0
Keywords
Online E-Journal full-text electronic free access open access J Can Res Ther online submissioncrystallization test crystals patterns cupric chloride oral squamous cell carcinoma

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