Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

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ID: 111254
2018
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Abstract
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.
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huang2018sensorsmatrix Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hao Huang;Huang, Hao;
Journal sensors
Year 2018
DOI
10.3390/s18103249
URL
https://www.mdpi.com/1424-8220/18/10/3249
Keywords
Biosensor Biomarker matrix metalloproteinases cancer detection matrix metalloproteinase-9 cancers

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