Enteropathies in the Developing World: Neglected Effects on Global Health

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ID: 111142
2012
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Abstract
Abstract. A spectrum of enteropathies, characterized by small intestinal inflammation, reduced absorptive capacity, and increased intestinal permeability, commonly affect people in developing countries. This subclinical intestinal pathology facilitates microbial translocation across the compromised intestinal barrier, leading to chronic systemic inflammation that may adversely impact health. Environmental enteropathy (EE), ubiquitous among people living in unhygienic conditions, likely mediates two interlinked public health problems of childhood, stunting and anemia, and underlies poor oral vaccine efficacy in developing countries. Human immunodeficiency virus (HIV) enteropathy, which frequently overlaps with EE, may contribute to immune activation and modulate HIV disease progression. The interacting effects of infection and enteropathy drive a vicious cycle that can propagate severe acute malnutrition, which underlies almost half of under-5-y deaths. Enteropathies are therefore highly prevalent, interacting causes of morbidity and mortality in developing countries. Interventions to prevent or ameliorate enteropathies have potential to improve the health of millions of people in developing countries.
Reference Key
prendergast2012theenteropathies Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andrew Prendergast;Paul Kelly;Andrew Prendergast;Paul Kelly;
Journal The American journal of tropical medicine and hygiene
Year 2012
DOI
doi:10.4269/ajtmh.2012.11-0743
URL
https://dx.doi.org/10.4269%2Fajtmh.2012.11-0743
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Public Health review humans pubmed abstract nih national institutes of health national library of medicine developing countries* Intestinal Diseases / epidemiology* pmid:22556071 pmc3335677 doi:10.4269/ajtmh.2012.11-0743 andrew prendergast paul kelly hiv enteropathy / diagnosis hiv enteropathy / epidemiology* hiv enteropathy / therapy intestinal diseases / diagnosis intestinal diseases / therapy morbidity

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