Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway

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ID: 110998
2017
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Abstract
In this study, we chose the PC12 cell line as a neuronal model, and our results demonstrate that nerve growth factor can induce autophagy with the neuroprotective effect and regulatory mechanisms of alcohol-induced autophagy in PC12 cells.
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l2017alcoholnerve Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu L;Sun T;Xin F;Cui W;Guo J;Hu J;;
Journal Alcohol and alcoholism (Oxford, Oxfordshire)
Year 2017
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/27760741
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine Ethanol / toxicity* Rats dose-response relationship drug pmid:27760741 doi:10.1093/alcalc/agw077 liping liu tiedong sun jian hu autophagy / drug effects autophagy / physiology nerve growth factor / pharmacology* neuroprotective agents / pharmacology* pc12 cells phosphatidylinositol 3-kinase / metabolism* phosphoinositide-3 kinase inhibitors proto-oncogene proteins c-akt / antagonists & inhibitors proto-oncogene proteins c-akt / metabolism* signal transduction / drug effects signal transduction / physiology tor serine-threonine kinases / antagonists & inhibitors tor serine-threonine kinases / metabolism*

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