Nanocharacterization of Soft Biological Samples in Shear Mode with Quartz Tuning Fork Probes

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ID: 110923
2012
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Abstract
Quartz tuning forks are extremely good resonators and their use is growing in scanning probe microscopy. Nevertheless, only a few studies on soft biological samples have been reported using these probes. In this work, we present the methodology to develop and use these nanosensors to properly work with biological samples. The working principles, fabrication and experimental setup are presented. The results in the nanocharacterization of different samples in different ambients are presented by using different working modes: amplitude modulation with and without the use of a Phase-Locked Loop (PLL) and frequency modulation. Pseudomonas aeruginosa bacteria are imaged in nitrogen using amplitude modulation. Microcontact printed antibodies are imaged in buffer using amplitude modulation with a PLL. Finally, metastatic cells are imaged in air using frequency modulation.
Reference Key
otero2012sensorsnanocharacterization Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jorge Otero;Laura Gonzalez;Manel Puig-Vidal;Otero, Jorge;Gonzalez, Laura;Puig-Vidal, Manel;
Journal sensors
Year 2012
DOI
10.3390/s120404803
URL
https://www.mdpi.com/1424-8220/12/4/4803/htm
Keywords
atomic force microscopy tuning fork nanocharacterization

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