A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

Clicks: 289
ID: 110891
2020
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Article Quality & Performance Metrics
Overall Quality Good Overall Quality
69.7 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment 🥈 High Quality
83.6 /100
Academic Rigor 88.0%
Novelty 70.0%
Clarity 85.0%
Key Strengths
  • Comprehensive overview of drug repurposing strategies
  • Focus on structural features and modes of action
  • Addresses various disease areas
Areas for Improvement
  • The abstract lacks specific examples of successful drug repurposing cases.
  • The review could benefit from a more in-depth discussion of the challenges and limitations of drug repurposing.
  • Limited discussion on the economic aspects of drug repurposing.
AI Recommendations

Consider adding a section on the economic benefits and challenges associated with drug repurposing. A more detailed discussion of the regulatory landscape surrounding drug repurposing would also be valuable. Include specific examples of successful drug repurposing cases with detailed mechanisms of action.

Enhanced v2.0 Analysis NISO/DORA Compliant
NISO/DORA Compliant
High Impact
📊 Established
Topic Trend
2025 Relevance
Relevance
0%
Importance
0%
Authorship
Unknown
Authors
0
Diversity
0%
Research Integrity
COPE Standards
Integrity
0%
Innovation
0%
Interdisciplinary Value
🔀 Cross-disciplinary
75%
Practical Impact Potential
Real-world Applications
80%
Enhanced Evaluation v2.0: Following NISO RP-25-2016, DORA 2025, and COPE assessment standards with 13 quality dimensions.
Readership in this journal
Emerging

Ranked #106 of 406 articles by views in European journal of medicinal chemistry

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Abstract
Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. The success rate of drugs repurposing approach accounts for approximately 30% of new FDA approved drugs and vaccines in recent years. This review focuses on the status of drugs repurposing approach for various diseases including skin diseases, infective, inflammatory, cancer, and neurodegenerative diseases. Efforts have been made to provide structural features and mode of actions of drugs.
Reference Key
2020europeana Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thanigaimalai Pillaiyar; Sangeetha Meenakshisundaram; Manoj Manickam; Murugesan Sankaranarayanan
Journal European journal of medicinal chemistry
Year 2020
DOI
10.1016/j.ejmech.2020.112275
URL
https://www.sciencedirect.com/science/article/pii/S0223523420302440##screen-reader-main-content
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