Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism

Clicks: 476
ID: 110733
1998
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Abstract
Adult rats intubated with a single dose of ethanol (alcohol; approximately 5 g/kg) for 5 to 10 successive days incur neurodegeneration in the entorhinal cortex, dentate gyrus, and olfactory bulbs accompanied by cerebrocortical edema and electrolyte (Na+, K+) accumulation. The brain damage is not les …
Reference Key
ma1998fasebbrain Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Collins MA;Zou JY;Neafsey EJ;;
Journal faseb journal : official publication of the federation of american societies for experimental biology
Year 1998
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/9472987
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Alcoholic Intoxication / pathology* Ethanol / toxicity* Rats Sprague-Dawley Organ Specificity pmid:9472987 doi:10.1096/fasebj.12.2.221 m a collins j y zou e j neafsey alcoholic intoxication / complications alcoholic intoxication / metabolism brain / drug effects brain / metabolism brain / pathology* brain edema / etiology brain edema / pathology dentate gyrus / pathology diuretics / pharmacology dizocilpine maleate / pharmacology entorhinal cortex / pathology excitatory amino acid antagonists / pharmacology furosemide / pharmacology* nerve degeneration / etiology nerve degeneration / pathology* neuroprotective agents* olfactory bulb / pathology organ culture techniques potassium / metabolism sodium / metabolism

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