Inflammation-restricted anti-inflammatory activities of a N-acylethanolamine acid amidase (NAAA) inhibitor F215

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ID: 110726
2018
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Abstract
N-Acylethanolamine acid amidase (NAAA) is a cysteine enzyme that catalyzes the hydrolysis of palmitoylethanolamide (PEA). Pharmacological blockage of NAAA elevates PEA levels and exerts powerful anti-inflammatory activities. We have recently identified a highly potent NAAA inhibitor F215. Here, we d …
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Authors Li Y;Zhou P;Chen H;Chen Q;Kuang X;Lu C;Ren J;Qiu Y;;
Journal pharmacological research
Year 2018
DOI
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https://www.pubmed.gov/?cmd=Search&term=yan+qiu+kuang
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Cells Cultured macrophages pmid:29572189 doi:10.1016/j.phrs.2018.03.011 yuhang li pan zhou yan qiu acute lung injury / chemically induced acute lung injury / drug therapy acute lung injury / pathology amidohydrolases / antagonists & inhibitors* anti-inflammatory agents / pharmacology anti-inflammatory agents / therapeutic use* edema / chemically induced edema / drug therapy enzyme inhibitors / pharmacology enzyme inhibitors / therapeutic use* lipopolysaccharides alveolar / drug effects inbred icr oxazoles / pharmacology oxazoles / therapeutic use* tetradecanoylphorbol acetate / analogs & derivatives

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