Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma

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ID: 110672
2020
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Abstract
Aim of the Study: Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies on the stage-specific expression of MMPs at different stages of larynx carcinoma are still lacking. In the present study, we compare the expression level of MMP-2 and MMP-9 at different stages of laryngeal carcinoma. Material and Methods: Tumor tissues samples were taken from larynx cancer patients by deep biopsy during direct laryngoscopy. Gene expression for MMP-2 and MMP-9 was analyzed using RT-PCR. Results: Significantly high expression of MMP-2 was observed compared to the MMP-9 at stage IV compared to the less advanced stages of the disease. Conclusion: Present study concluded that the MMP-2 expressed with a greater magnitude as compared to the MMP-9 in advance stages of laryngeal carcinoma.
Reference Key
bakshi2020journalstage-specific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bakshi;Jaimanti Bakshi;Atul Kumar Goyal;Virender Singh;Malay Sannigrahi;Madhu Khullar;
Journal journal of cancer research and therapeutics
Year 2020
DOI
0973-1482
URL
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=517;epage=520;aulast=Bakshi;type=3
Keywords
cancer Online E-Journal full-text electronic free access open access gene expression Journal of Cancer Research and Therapeutics online submissionbiopsy laryngeal matrix metalloproteinases

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