Evaluation of the protective efficacy of reshaped human monoclonal antibody RSHZ19 against respiratory syncytial virus in cotton rats

Clicks: 458
ID: 110516
1995
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Abstract
Reshaped human MAb RSHZ19, which is specific for the surface fusion protein of respiratory syncytial virus (RSV) is in clinical development for the prevention and treatment of RSV-induced disease in human infants. The current studies profile lung virus clearance and evaluate lung histopathology in M …
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Authors Wyde PR;Moore DK;Hepburn T;Silverman CL;Porter TG;Gross M;Taylor G;Demuth SG;Dillon SB;;
Journal Pediatric research
Year 1995
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8559607
Keywords
immunization National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't Disease Models Animal Infant Comparative Study P.H.S. Antibodies Monoclonal Humanized respiratory syncytial viruses / immunology* pmid:8559607 doi:10.1203/00006450-199510000-00012 p r wyde d k moore s b dillon monoclonal / pharmacokinetics monoclonal / pharmacology* monoclonal / therapeutic use viral / blood bronchoalveolar lavage fluid / immunology evaluation studies as topic passive in vitro techniques lung / pathology neutralization tests respiratory syncytial virus infections / immunology respiratory syncytial virus infections / prevention & control* respiratory syncytial virus infections / therapy sigmodontinae viral fusion proteins / immunology

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