Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

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ID: 110291
2019
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Abstract
Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 ca …
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Authors Chen K;Luan X;Liu Q;Wang J;Chang X;Snijders AM;Mao JH;Secombe J;Dan Z;Chen JH;Wang Z;Dong X;Qiu C;Chang X;Zhang D;Celniker SE;Liu X;;
Journal cell host & microbe
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/30902578/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Drosophila animals humans pubmed abstract nih national institutes of health national library of medicine behavior research support non-u.s. gov't female male N.I.H. Extramural Disease Models Animal pmid:30902578 pmc6749836 doi:10.1016/j.chom.2019.02.003 kun chen xiaoting luan xingyin liu autism spectrum disorder / enzymology autism spectrum disorder / immunology autism spectrum disorder / microbiology* autism spectrum disorder / psychology drosophila proteins / genetics drosophila proteins / metabolism* drosophila melanogaster / enzymology* drosophila melanogaster / immunology* drosophila melanogaster / microbiology drosophila melanogaster / physiology gastrointestinal microbiome* histone demethylases / genetics histone demethylases / metabolism* intestinal mucosa / immunology intestinal mucosa / microbiology* social behavior

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