Silicon Photonic Biosensors Using Label-Free Detection

Clicks: 318
ID: 110229
2018
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Abstract
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.
Reference Key
luan2018sensorssilicon Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Enxiao Luan;Hossam Shoman;Daniel M. Ratner;Karen C. Cheung;Lukas Chrostowski;Luan, Enxiao;Shoman, Hossam;Ratner, Daniel M.;Cheung, Karen C.;Chrostowski, Lukas;
Journal sensors
Year 2018
DOI
10.3390/s18103519
URL
https://www.mdpi.com/1424-8220/18/10/3519#citedby
Keywords
microfluidics lab-on-a-chip photonic crystal bragg grating silicon photonics evanescent optical field sensor label-free soi biosensor mach–zehnder interferometer ring resonator sub-wavelength grating

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