Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression

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2000
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Abstract
We have constructed a recombinant adenovirus gene delivery system that is capable of undergoing growth phase-dependent site-specific recombination. When propagated in 293 producer cells, the vector retains its linear double-stranded form and can be propagated to high titer and purified by convention …
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Authors Wang X;Zeng W;Murakawa M;Freeman MW;Seed B;;
Journal Journal of Virology
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11070029
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic gene expression humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Cells Cultured pmid:11070029 pmc113234 doi:10.1128/jvi.74.23.11296-11303.2000 x wang w zeng b seed adenoviridae / genetics* enhancer elements genetic* gene rearrangement* gene transfer horizontal genetic vectors* herpesvirus 4 human / genetics* plasmids polymerase chain reaction recombination

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