Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

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ID: 110123
2018
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Abstract
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy num …
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Authors Gao Q;Liang WW;Foltz SM;Mutharasu G;Jayasinghe RG;Cao S;Liao WW;Reynolds SM;Wyczalkowski MA;Yao L;Yu L;Sun SQ; ; ;Chen K;Lazar AJ;Fields RC;Wendl MC;Van Tine BA;Vij R;Chen F;Nykter M;Shmulevich I;Ding L;;
Journal Cell reports
Year 2018
DOI
DOI not found
URL
https://www.pubmed.gov/29617662/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural pmid:29617662 pmc5916809 doi:10.1016/j.celrep.2018.03.050 qingsong gao wen-wei liang li ding antineoplastic agents / pharmacology* antineoplastic agents / therapeutic use carcinogenesis / drug effects carcinogenesis / genetics* carcinogenesis / metabolism cell line molecular targeted therapy / methods neoplasms / drug therapy neoplasms / genetics* neoplasms / pathology oncogene fusion* oncogene proteins fusion / chemistry fusion / genetics fusion / metabolism

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