Waveguide-Mode Sensors as Aptasensors

Clicks: 329
ID: 110116
2012
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Abstract
Aptamers are artificial nucleic acid ligands that can be generated by in vitro selection through partition and amplification. Aptamers can be generated against a wide range of biomolecules through the formation of versatile stem-loop structures. Because aptamers are potential substitutes for antibodies and drugs, the development of an aptamer-based sensor (aptasensor) is mandatory for diagnosis. We previously reported that waveguide-mode sensors are useful in the analysis of a wide range of biomolecular interactions, including aptamers. The advantages of the waveguide-mode sensor that we developed include physical and chemical stability and that higher sensitivity can be achieved with ease by perforating the waveguide layer or using colored materials such as dyes or metal nanoparticles as labels. Herein, we provide an overview of the strategies and applications for aptamer-based analyses using waveguide-mode sensors.
Reference Key
gopinath2012sensorswaveguide-mode Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Subash C. B. Gopinath;Koichi Awazu;Makoto Fujimaki;Gopinath, Subash C. B.;Awazu, Koichi;Fujimaki, Makoto;
Journal sensors
Year 2012
DOI
10.3390/s120202136
URL
https://www.mdpi.com/1424-8220/12/2/2136
Keywords
aptamer aptasensor optics selex waveguide

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