Magnetic Nanomaterials as Contrast Agents for MRI

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ID: 109991
2020
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Abstract
Magnetic Resonance Imaging (MRI) is a powerful, noninvasive and nondestructive technique, capable of providing three-dimensional (3D) images of living organisms. The use of magnetic contrast agents has allowed clinical researchers and analysts to significantly increase the sensitivity and specificity of MRI, since these agents change the intrinsic properties of the tissues within a living organism, increasing the information present in the images. Advances in nanotechnology and materials science, as well as the research of new magnetic effects, have been the driving forces that are propelling forward the use of magnetic nanostructures as promising alternatives to commercial contrast agents used in MRI. This review discusses the principles associated with the use of contrast agents in MRI, as well as the most recent reports focused on nanostructured contrast agents. The potential applications of gadolinium- (Gd) and manganese- (Mn) based nanomaterials and iron oxide nanoparticles in this imaging technique are discussed as well, from their magnetic behavior to the commonly used materials and nanoarchitectures. Additionally, recent efforts to develop new types of contrast agents based on synthetic antiferromagnetic and high aspect ratio nanostructures are also addressed. Furthermore, the application of these materials in theragnosis, either as contrast agents and controlled drug release systems, contrast agents and thermal therapy materials or contrast agents and radiosensitizers, is also presented.
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caspani2020materialsmagnetic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sofia Caspani;Ricardo Magalhães;João Pedro Araújo;Célia Tavares Sousa;Caspani, Sofia;Magalhães, Ricardo;Araújo, João Pedro;Sousa, Célia Tavares;
Journal Materials (Basel, Switzerland)
Year 2020
DOI
10.3390/ma13112586
URL
https://www.mdpi.com/1996-1944/13/11/2586
Keywords
MRI nanomaterials nanowires iron oxide nanoparticles contrast agents gd-based contrast agents mn-based contrast agents magnetic nanodiscs synthetic antiferromagnetic nanostructures theragnosis National Center for Biotechnology Information NCBI NLM MEDLINE review pubmed abstract nih national institutes of health national library of medicine pmid:32517085 pmc7321635 doi:10.3390/ma13112586 sofia caspani ricardo magalhães célia tavares sousa

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