Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones

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ID: 10999
2011
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Abstract
2-(Arylsulfonyl)indane-1,3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1,3-dione, we have synthesized them (7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the presence of pyridine-piperidine medium for the first time. The synthesized 2-(arylsulfonyl)indane-1,3-diones were evaluated for antimicrobial and anticoagulant activities and all of them registered significant activity.
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malaichamy2011synthesisorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jeyachandran, Malaichamy;Ramesh, Penugonda;Jeyachandran, Malaichamy;Ramesh, Penugonda;
Journal organic chemistry international
Year 2011
DOI
10.1155/2011/360810
URL
https://www.hindawi.com/journals/oci/2011/360810/abs/
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