HIV through the looking glass: insights derived from Hepatitis B.

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ID: 109845
2015
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Ranked #23 of 28 articles by views in Journal of acquired immune deficiency syndromes (1999)

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Abstract
Although higher levels of hepatitis B virus (HBV) replication in HIV-HBV co-infection may relate to liver disease progression, this has not been completely elucidated. We used expression of hepatitis B core antigen (HBcAg) in liver biopsies from HIV-HBV co-infected and HBV mono-infected patients as a marker for HBV replication, and related these findings to clinical and histological parameters.Data from 244 HBV patients were compared with 34 HIV-HBV patients. Liver biopsies were scored for inflammation, fibrosis, HBcAg, and hepatitis B surface antigen. Univariate and multivariate analyses were performed.HBcAg, but not hepatitis B surface antigen, staining was stronger in HIV co-infected than in HBV mono-infected. Co-infected and HBV mono-infected had similar alanine aminotransferase, inflammatory and fibrosis scores, and hepatitis B e antigen status. HBcAg staining correlated with HIV after correcting for HBV DNA and hepatitis B e antigen. CD4 counts and HIV RNA level did not correlate with intensity of HBcAg staining. HBV DNA levels were higher in HIV co-infected and correlated with HBcAg staining.By looking at HBcAg as a reflection of HBV replication in HIV-HBV co-infected with controlled HIV, our findings suggest that these patients may have subtle immune function defects, which could lead to adverse liver disease outcomes.
Reference Key
rivera2015hivjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rivera, Maria M;Soza, Alejandro;Jazwinski, Alison;Mi, Lijun;Kleiner, David E;Zhao, Xiongce;Zuber, Charma;Brust, Douglas;Hsu, Emory;Simpson, Jennifer;Hoofnagle, Jay H;Heller, Theo;
Journal Journal of acquired immune deficiency syndromes (1999)
Year 2015
DOI
10.1097/QAI.0000000000000415
URL
Keywords
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