Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam.

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ID: 109036
2020
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Abstract
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.
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Authors Phan, Lan T;Nguyen, Thuong V;Huynh, Loan K T;Dao, Manh H;Vo, Tho A N;Vu, Nhung H P;Pham, Hang T T;Nguyen, Hieu T;Nguyen, Thuc T;Le, Hung Q;Nguyen, Thinh V;Nguyen, Quan H;Huynh, Thao P;Nguyen, Sang N;Nguyen, Anh H;Nguyen, Ngoc T;Nguyen, Thao N T;Nguyen, Long T;Luong, Quang C;Cao, Thang M;Pham, Quang D;
Journal Journal of medical virology
Year 2020
DOI
10.1002/jmv.26075
URL
Keywords
coronavirus respiratory infections covid-19 sars-cov-2 vero complete genome sequencing

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