Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells.

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ID: 108648
2020
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Abstract
We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notably, this method also allowed us to quantitatively monitor the cell responses by agonists and antagonists of nAChRs. These results suggest that our ion-selective CNT-FET sensor has potential uses in biological and medical researches such as the monitoring of ion-channel activity and the screening of drugs.
Reference Key
cho2020ionselectivesensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Youngtak Cho, Viet Anh Pham Ba, Jin-Young Jeong, Yoonji Choi, Seunghun Hong
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Journal sensors
Year 2020
DOI
E3680
URL
Keywords
ion channel nicotinic acetylcholine receptor carbon nanotube field-effect transistor ion-selective membrane valinomycin

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