Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells.

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ID: 108648
2020
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Abstract
We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notably, this method also allowed us to quantitatively monitor the cell responses by agonists and antagonists of nAChRs. These results suggest that our ion-selective CNT-FET sensor has potential uses in biological and medical researches such as the monitoring of ion-channel activity and the screening of drugs.
Reference Key
cho2020ionselectivesensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cho, Youngtak;Pham Ba, Viet Anh;Jeong, Jin-Young;Choi, Yoonji;Hong, Seunghun;
Journal sensors
Year 2020
DOI
E3680
URL
Keywords
ion channel nicotinic acetylcholine receptor carbon nanotube field-effect transistor ion-selective membrane valinomycin

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