Antagonists D1 and D2 of Dopamine Receptors Determine Different Mechanisms of Neuroprotective Action in the Frog Vestibular.

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ID: 108644
2020
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Abstract
The high functional plasticity of the glutamatergic synapse of the vestibular epithelium is supported by a delicate balance of excitatory and inhibitory interactions. One of the peptides co-localized with acetylcholine (ACh) in the efferent fibers is dopamine. Using external perfusion of the synaptic zone and multiunit recording of an afferent fibers activity the effect of dopamine antagonists on the background firing rate of the semicircular canal sensory fibers was studied on the isolated frog vestibular. The present research revealed that the dopamine receptor antagonist (D1) SCH-23390 significantly reduced the level of background activity at high concentrations. In contrast, D2 antagonist eticlopride caused positive-negative answer of the background activity of the sensory fibers in dose-depending manner. The data confirm the hypothesis that dopamine, being tonic released from the efferent fibers, realizes neuroprotective inhibitory control over the afferent glutamatergic synapse activity in the vestibular epithelium via D1 and D2 receptors.
Reference Key
ryzhova2020antagonistsdoklady Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ryzhova, I V;Tobias, T V;Nozdrachev, A D;
Journal doklady biochemistry and biophysics
Year 2020
DOI
10.1134/S1607672920030084
URL
Keywords
dopamine neuroprotection d1 and d2 dopamine receptors glutamatergic synapse hair cell vestibular apparatus

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