Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-Orthogonal Chemistry and Their Use as Responsive Delivery Systems.

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ID: 108592
2020
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Abstract
Bio-orthogonal reactions have become an essential tool to prepare biomaterials; for example, in the synthesis of nanocarriers, bio-orthogonal chemistry allows circumventing common obstacles related to the encapsulation of delicate payloads or the occurrence of uncontrolled side reactions, which significantly limit the range of potential payloads to encapsulate. Here, we report a new approach to prepare pH-responsive nanocarriers using dynamic bio-orthogonal chemistry. The reaction between a poly(hydrazide) crosslinker and functionalized polysaccharides was used to form a pH-responsive hydrazone network. The network formation occurred at the interface of aqueous nanodroplets in miniemulsion and led to the production of nanocapsules that were able to encapsulate payloads of different molecular weights. The resulting nanocapsules displayed low cytotoxicity and were able to release the encapsulated payload, in a controlled manner, under mildly acidic conditions.
Reference Key
alkanawati2020polysaccharidebasedbiomacromolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alkanawati, Mohammad Shafee;da Costa Marques, Richard;Mailänder, Volker;Landfester, Katharina;Thérien-Aubin, Héloïse;
Journal Biomacromolecules
Year 2020
DOI
10.1021/acs.biomac.0c00492
URL
Keywords
Hydrazone Cytotoxicity reactive oxygen species nitrofurans nitroreduction

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