Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti- Agents.

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ID: 108584
2020
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Abstract
In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.
Reference Key
alnufaie2020synthesismolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alnufaie, Rawan;Raj Kc, Hansa;Alsup, Nickolas;Whitt, Jedidiah;Andrew Chambers, Steven;Gilmore, David;Alam, Mohammad A;
Journal molecules
Year 2020
DOI
E2758
URL
Keywords
Hydrazone Antimicrobial staphylococcus aureus biofilm S. epidermidis mrsa pyrazole coumarin

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