Synthesis and modification of crystalline SBA-15 nanowhiskers as a pH-sensitive metronidazole nanocarrier system.

Clicks: 253
ID: 108430
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #136 of 245 articles by views in International journal of pharmaceutics

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 245 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Clinical resistance to drugs and diminution in their side effects have become great issues for pharmacologists. In veterinary medicine, parasites like Trichomonas gallinae are of veterinary, hygienic and economic importance and can be treated by metronidazole. Unfortunately, scientific evidence has been reported about its resistance and serious side effects in trichomoniasis. In this research, it was attempted to introduce a new procedure to lower side effects of the drug molecules and also, enhance the treatment of disease. Whisker-formed SBA-15 nanoparticles were utilized for the first time in this issue. They had mesoporous structures which metronidazole molecules could be trapped in them. Additionally, these crystalline nanowhiskers were modified with tannic acid to make the release process better. The branches of tannic acid covered the opening of pores in crystalline SBA-15 nanowhiskers and restricted the drug from fast release. It caused a controlled metronidazole release in the smart drug delivery. These nanocarriers were completely tested by several experiments. Whisker-like SBA-15 nanocrystals had a mesopore volume of 0.5931 cm/g, pore diameter of 6.06 nm and surface area of 491.38 m/g. Based on TGA analysis, 10% of tannic acid was coated on the crystalline nanowhiskers during the modification. The metronidazole content and entrapment efficiency of final nanocarriers was 28.56% and 71.40%, respectively. The decomposition of tannic acid in lower pHs made whisker-like SBA-15@tannic acid nanocrystals be pH-responsive which can be used for other applications in the pharmacology. In-vitro study revealed that the minimal lethal concentration of nanocarriers was 0.5 mg/mL for 180 min.
Reference Key
yunessnia-lehi2019synthesisinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yunessnia Lehi, Arash;Shagholani, Hamidreza;Nikpay, Ali;Ghorbani, Mohsen;Soleimani Lashkenari, Mohammad;Soltani, Maryam;
Journal International journal of pharmaceutics
Year 2019
DOI
S0378-5173(18)30852-4
URL
Keywords
Metronidazole ph-sensitive release nanowhiskers sba-15 smart drug delivery trichomonas gallinae

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.