Evaluation of rapid antigen test for detection of SARS-CoV-2 virus.

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ID: 108161
2020
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Abstract
The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests.To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test.The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 10 fold less sensitive than viral culture while RAD was 10 fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients.This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.
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Authors Mak, Gannon Ck;Cheng, Peter Kc;Lau, Stephen Sy;Wong, Kitty Ky;Lau, C S;Lam, Edman Tk;Chan, Rickjason Cw;Tsang, Dominic Nc;
Journal journal of clinical virology : the official publication of the pan american society for clinical virology
Year 2020
DOI
S1386-6532(20)30242-0
URL
Keywords
viral culture rt-pcr covid-19 sars-cov-2 2019 novel coronavirus rapid antigen detection

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