Antidiabetic Indian plants: a good source of potent amylase inhibitors.

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ID: 107775
2011
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Ranked #25 of 32 articles by views in Evidence-based complementary and alternative medicine : eCAM

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Abstract
Diabetes is known as a multifactorial disease. The treatment of diabetes (Type II) is complicated due to the inherent patho-physiological factors related to this disease. One of the complications of diabetes is post-prandial hyperglycemia (PPHG). Glucosidase inhibitors, particularly α-amylase inhibitors are a class of compounds that helps in managing PPHG. Six ethno-botanically known plants having antidiabetic property namely, Azadirachta indica Adr. Juss.; Murraya koenigii (L.) Sprengel; Ocimum tenuflorum (L.) (syn: Sanctum); Syzygium cumini (L.) Skeels (syn: Eugenia jambolana); Linum usitatissimum (L.) and Bougainvillea spectabilis were tested for their ability to inhibit glucosidase activity. The chloroform, methanol and aqueous extracts were prepared sequentially from either leaves or seeds of these plants. It was observed that the chloroform extract of O. tenuflorum; B. spectabilis; M. koenigii and S. cumini have significant α-amylase inhibitory property. Plants extracts were further tested against murine pancreatic, liver and small intestinal crude enzyme preparations for glucosidase inhibitory activity. The three extracts of O. tenuflorum and chloroform extract of M. koenigi showed good inhibition of murine pancreatic and intestinal glucosidases as compared with acarbose, a known glucosidase inhibitor.
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bhat2011antidiabeticevidencebased Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bhat, Menakshi;Zinjarde, Smita S;Bhargava, Shobha Y;Kumar, Ameeta Ravi;Joshi, Bimba N;
Journal Evidence-based complementary and alternative medicine : eCAM
Year 2011
DOI
10.1093/ecam/nen040
URL
Keywords Keywords not found

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