Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine
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2010
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Abstract
A series of 2-substituted and 2,3-substituted quinazolin -4(3H)-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.
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| Authors | Sen, Debanjan;Banerjee, Anirban;Ghosh, Ashoke Kumar;Chatterjee, Tapan Kumar; |
| Journal | journal of advanced pharmaceutical technology & research |
| Year | 2010 |
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