Protection against Shiga Toxins

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ID: 107748
2017
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Abstract
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, where it inhibits protein synthesis and in some cell types induces apoptosis. Protection of cells can be provided either by inhibiting binding of the toxin to cells or by interfering with any of the subsequent steps required for its toxic effect. In this article we provide a brief overview of the interaction of Shiga toxins with cells, describe some compounds and conditions found to protect cells against Shiga toxins, and discuss whether they might also provide protection in animals and humans.
Reference Key
kavaliauskiene2017protectiontoxins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kavaliauskiene, Simona;Lingelem, Anne Berit Dyve;Skotland, Tore;Sandvig, Kirsten;
Journal Toxins
Year 2017
DOI
DOI not found
URL
http://www.mdpi.com/2072-6651/9/2/44
Keywords
chemistry Infectious and parasitic diseases Medicine (General) Medicine Science (General) Agriculture (General) pharmaceutical industry

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