Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro

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ID: 107742
2018
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Abstract
In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.
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kristina2018chloroquineacta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kristina, Pavić;Zrinka, Rajić;Zvonimir, Mlinarić;Lidija, Uzelac;Marijeta, Kralj;Branka, Zorc;
Journal acta pharmaceutica
Year 2018
DOI
DOI not found
URL
http://www.degruyter.com/view/j/acph.2018.68.issue-4/acph-2018-0039/acph-2018-0039.xml?format=INT
Keywords
chemistry pharmaceutical industry

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