Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro
Clics: 256
ID: 107742
2018
Metricas de Calidad y Rendimiento del Articulo
Calidad General
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Participacion del Lector
Emerging Content
30.0
/100
256 vistas
31 lectores
Evaluacion de Calidad por IA
No analizado
Readership in this journal
EmergingRanked #24 of 56 articles by views in acta pharmaceutica
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Resumen
In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.
| Clave de Referencia |
kristina2018chloroquineacta
Use esta clave para autocitar en el manuscrito mientras usa
SciMatic Manuscript Manager o Thesis Manager
|
|---|---|
| Autores | Kristina, Pavić;Zrinka, Rajić;Zvonimir, Mlinarić;Lidija, Uzelac;Marijeta, Kralj;Branka, Zorc; |
| Revista | acta pharmaceutica |
| Ano | 2018 |
| DOI |
DOI no encontrado
|
| URL | |
| Palabras Clave |
Citas
No se encontraron citas. Para agregar una cita, contacte al administrador en info@scimatic.org
Comentarios
Aun no hay comentarios. Sea el primero en comentar este articulo.