The initiation of post-synaptic protrusions

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ID: 107543
2016
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Abstract
The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions.
Reference Key
hotulainen2016thecommunicative Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hotulainen, Pirta;Saarikangas, Juha;
Journal communicative & integrative biology
Year 2016
DOI
DOI not found
URL
http://dx.doi.org/10.1080/19420889.2015.1125053
Keywords
Nursing Biology (General) philology. linguistics language and literature english literature history of great britain

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