The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.

Clicks: 182
ID: 107293
1990
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Abstract
B cells can function as antigen-presenting cells and accessory cells for T cell responses. This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL). B cell-deficient mice exhibited significantly reduced tumor-specific CD4+ helper and CD8+ cytotoxic T cell responses after priming with FBL or a recombinant vaccinia virus containing F-MuLV antigens. Moreover, these mice had diminished T cell responses to the vaccinia viral antigens. Tumor-primed T cells transferred into B cell-deficient mice effectively eradicated disseminated FBL. Thus, B cells appear necessary for efficient priming but not expression of tumor and viral T cell immunity.
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Authors K R Schultz, J P Klarnet, R S Gieni, K T HayGlass, P D Greenberg
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Journal science (new york, ny)
Year 1990
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