The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.

Clicks: 165
ID: 107293
1990
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Abstract
B cells can function as antigen-presenting cells and accessory cells for T cell responses. This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL). B cell-deficient mice exhibited significantly reduced tumor-specific CD4+ helper and CD8+ cytotoxic T cell responses after priming with FBL or a recombinant vaccinia virus containing F-MuLV antigens. Moreover, these mice had diminished T cell responses to the vaccinia viral antigens. Tumor-primed T cells transferred into B cell-deficient mice effectively eradicated disseminated FBL. Thus, B cells appear necessary for efficient priming but not expression of tumor and viral T cell immunity.
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schultz1990thescience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Schultz, K R;Klarnet, J P;Gieni, R S;HayGlass, K T;Greenberg, P D;
Journal science (new york, ny)
Year 1990
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