Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles.

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ID: 107143
2020
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Abstract
Phospholipids constitute biocompatible and safe excipients for pulmonary drug delivery. They can retard the drug release and, when PEGylated, also prolong the residence time in the lung. The aim of this work was to assess the structure and coherence of phospholipid coatings formed by spray drying on hydrophilic surfaces (silica microparticles) on the nanoscale and, in particular, the effect of addition of PEGylated lipids thereon. Scanning electron microscopy showed the presence of nanoparticles of varying sizes on the microparticles with different PEGylated lipid concentrations. Atomic force microscopy confirmed the presence of a lipid coating on the spray-dried microparticles. It also revealed that the lipid-coated microparticles without PEGylated lipids had a rather homogenous coating whereas those with PEGylated lipids had a very heterogeneous coating with defects, which was corroborated by confocal laser scanning microscopy. All coated microparticles had good dispersibility without agglomerate formation, as indicated by particle size measurements. This study has demonstrated that coherent coatings of phospholipids on hydrophilic surfaces can be obtained by spray drying. However, the incorporation of PEGylated lipids in a one-step spray-drying process to prepare lipid coated microparticles with both controlled-release and stealth properties is very challenging.
Reference Key
an2020nanoscalejournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors An, Junxue;Forchheimer, Daniel;Sävmarker, Jonas;Brülls, Mikael;Frenning, Göran;
Journal Journal of colloid and interface science
Year 2020
DOI
S0021-9797(20)30630-5
URL
Keywords
spray drying controlled release lipid coated microparticle pegylated microparticle pegylated surface pulmonary dry powder solid lipid microparticle

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