Environmental transformation of n-TiO in the aquatic systems and their ecotoxicity in bivalve mollusks: A systematic review.

Over the past decades, titanium dioxide nanoparticles (n-TiO) have been extensively used in several industrial applications and the manufacture of novel consumer products. Although strict regulations have been put in place to limit their release into the aquatic environment, these nanoparticles can still be found at elevated levels within the environment, which can result in toxic effects on exposed organisms and has possible implications in term of public health. Bivalve mollusks are a unique and ideal group of shellfish for the study and monitoring the aquatic pollution by n-TiO because of their filter-feeding behaviour and ability to accumulate toxicants in their tissues. In these animals, exposure to n-TiO leads to oxidative stress, immunotoxicity, neurotoxicity, and genotoxicity, as well as behavioral and physiological changes. This review summarizes the uptake, accumulation, and fate of n-TiO in aquatic environments and the possible interactions between n-TiO and other contaminants such as heavy metals and organic pollutants. Moreover, the toxicological impacts and mechanisms of action are discussed for a wide range of bivalve mollusks. This data underlines the pressing need for additional knowledge and future research plans for the development of control strategies to mitigate the release of n-TiO to the aquatic environment to prevent the toxicological impacts on bivalves and protect public health.