Assessment of Ploy Dopamine Coated Fe3O4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection.

Clicks: 387
ID: 107110
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #6 of 96 articles by views in anti-cancer agents in medicinal chemistry

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Poly dopamine coated iron oxide nanoparticles (FeO@PDA NPs) were synthesized, characterized, and their MR imaging contrast agents and photothermal potency were evaluated on melanoma (B16-F10 and A-375) cells and normal skin cell. To this end, MTT assay, Fe concentration, and MR imaging of both coated and uncoated NPs were assessed in C57BL/6 mice.Fe3O4 nanoparticles were synthesized using co-precipitation, and coated with poly dopamine. The cytotoxicity of FeO and FeO@PDA NPs on melanoma cells with different concentrations were obtained using MTT assay. MR images and Fe concentration, of nanoprobe and nanoparticles were evaluated under in vivo conditions.Findings indicated that uncoated FeO showed the highest toxicity on animal (B16- F10) cells at 450µg/ml after 72h, while the highest toxicity in human (A-375) cells were observed at 350µg/ml. These nanoparticles did not reveal any cytotoxicity to normal skin cells, despite having some toxicity features in A-375 cells. MR image signals in tumor were low compared with other tissues. The iron concentration in tumor was higher than that of other organs.It is concluded that the cytotoxicity of FeO@PDA were found to be significantly lower than uncoated nanoparticles (p <0.001) which allow some positive effects on reducing toxicity. The prepared nanoprobe may be used as contrast agent in MR imaging.
Reference Key
beigi2020assessmentanticancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Beigi, Fahimeh H;Fatahian, Soheil;Shahbazi-Gahrouei, Sogand;Shahbazi-Gahrouei, Daryoush;Farzadniya, Amin;
Journal anti-cancer agents in medicinal chemistry
Year 2020
DOI
10.2174/1871520620666200513084616
URL
Keywords
Cytotoxicity mr imaging a-375 b16-f10 fe3o4 fe3o4@pda nps

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.