IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis

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ID: 106929
2017
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Abstract
Abstract Background Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis. Here, we investigated whether IL-32 is also expressed in patient lesions caused by L. amazonensis. In addition, we evaluated experimental L. amazonensis and L. braziliensis infections in C57BL/6 transgenic mice for human IL-32γ (IL-32γTg) in comparison with wild-type (WT) mice that do not express the IL-32 gene. Results Human cutaneous lesions caused by L. amazonensis express higher levels of IL-32 than healthy control skin. In mice, the presence of IL-32γ promoted the control of cutaneous lesions caused by L. braziliensis, but not lesions caused by L. amazonensis in an ear dermis infection model. In addition, IL-32γTg mice displayed less tissue parasitism and inflammation in IL-32γTg than WT mice during the healing phase of L. braziliensis infection. Production of antigen-specific pro-inflammatory cytokines was higher in IL-32γTg mice than in WT mice during L. braziliensis infection but not during L. amazonensis infection. Conclusions Human cutaneous lesions caused by L. amazonensis express high levels of IL-32. In mice, the presence of IL-32γ contributes to the lesion healing caused by L. braziliensis but not by L. amazonensis. Data suggest that despite the ability for both species to induce IL-32 in humans, the connections between this cytokine and other immune players induced by related species of parasites can lead to distinct outcomes of the murine infections.
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Authors Gomes, Rodrigo Saar;Silva, Muriel Vilela Teodoro;Santos, Jéssica Cristina dos;Silva, Lucas Luiz de Lima;Batista, Aline Carvalho;Machado, Juliana Reis;Teixeira, Mauro Martins;Dorta, Miriam Leandro;Oliveira, Milton Adriano Pelli de;Dinarello, Charles A;Joosten, Leo A. B.;Ribeiro-Dias, Fátima;
Journal Parasites & vectors
Year 2017
DOI
DOI not found
URL
http://link.springer.com/article/10.1186/s13071-017-2268-4
Keywords
Infectious and parasitic diseases Medicine (General) Medicine Science Diseases of the blood and blood-forming organs public aspects of medicine arctic medicine. tropical medicine communication. mass media

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