[Hydroxychloroquine. Cardiology's viewpoint in times of coronavirus pandemic].

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ID: 106863
2020
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Abstract
Due to the coronavirus disease 2019 (COVID-19) pandemic, a wide number of compounds are under scrutiny regarding their antiviral activity, one of them being hydroxychloroquine. Cardiac aspects of the use of chloroquine and hydroxychloroquine are reviewed in this manuscript. A non-systematic review of the medical literature was performed. Information about their safety and efficacy as antimalarials, antivirals, as well as in the long-term treatment of rheumatic diseases was collected. We found an anti-inflammatory effect with reduction of longterm cardiovascular events, a very infrequent heart disease due to a lysosomal effect of the drug, and at the hemodynamic level hypotension, tachycardia, and QT interval prolongation, exacerbated when combined with azithromycin. However, the rate of adverse cardiac events of hydroxychloroquine (and chloroquine) was low.
Reference Key
zaidel2020hydroxychloroquinemedicina Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zaidel, Ezequiel J;Wyss Quintana, Fernando S;Sosa Liprandi, Álvaro;Mendoza, Iván;Márquez, Manlio F;Nuñez, Elaine;Barbosa, Marcia;Baranchuk, Adrián;
Journal medicina
Year 2020
DOI
DOI not found
URL URL not found
Keywords
coronavirus hydroxychloroquine cardiovascular system long qt syndrome pandemic chloroquine covid-19 azithromycin

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