A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.

Clicks: 269
ID: 106729
2020
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #11 of 22 articles by views in Genetics

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The microbiome influences health and disease through complex networks of host genetics, genomics, microbes, and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in laboratory mice () enables data-driven discovery of biological network components and mechanisms of host-microbial interactions underlying disease phenotypes. To examine the interplay among the whole host genome, transcriptome, and microbiome, we mapped QTL and correlated the abundance of cecal messenger RNA, luminal microflora, physiology, and behavior in a highly diverse Collaborative Cross breeding population. One such relationship, regulated by a variant on chromosome 7, was the association of (Bacteroidales) abundance and sleep phenotypes. In a test of this association in the BKS.Cg- +/+ J mouse model of obesity and diabetes, known to have abnormal sleep and colonization by , treatment with antibiotics altered sleep in a genotype-dependent fashion. The many other relationships extracted from this study can be used to interrogate other diseases, microbes, and mechanisms.
Reference Key
bubier2020agenetics Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bubier, Jason A;Philip, Vivek M;Quince, Christopher;Campbell, James;Zhou, Yanjiao;Vishnivetskaya, Tatiana;Duvvuru, Suman;Blair, Rachel Hageman;Ndukum, Juliet;Donohue, Kevin D;Foster, Carmen M;Mellert, David J;Weinstock, George;Culiat, Cymbeline T;O'Hara, Bruce F;Palumbo, Anthony V;Podar, Mircea;Chesler, Elissa J;
Journal Genetics
Year 2020
DOI
10.1534/genetics.119.303013
URL
Keywords
behavior sleep genetics genomics bioinformatics

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.