Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?

Clicks: 293
ID: 106620
2020
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Ranked #44 of 167 articles by views in Behavioural brain research

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Abstract
Depression is a leading cause of disability, with often chronic course of illness and high treatment resistance in a large proportion of patients. In the current short perspective paper, we present evidence supporting the presence of synaptic-based chronic stress pathology (CSP) in depression and across a number of psychiatric disorders. We summarize the synaptic connectivity model of CSP, and briefly review related preclinical and clinical evidence, while providing appropriate references for more comprehensive reviews and alternative models. We then underscore some gaps in the literature and provide various tips for future directions.
Reference Key
abdallah2020ketaminebehavioural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Abdallah, Chadi G;Krystal, John H;
Journal Behavioural brain research
Year 2020
DOI
S0166-4328(20)30327-2
URL
Keywords
depression rapamycin antidepressants ketamine synaptic plasticity relapse prevention

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