In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

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ID: 10625
2019
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Abstract
Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.
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Authors Nguyen, Tan Dat;Nguyen, Thanh Truc;Ly, Khanh Loan;Tran, Anh Hien;Nguyen, Thi Thanh Ngoc;Vo, Minh Thuy;Ho, Hieu Minh;Dang, Ngoc Thao Nhi;Vo, Van Toi;Nguyen, Dai Hai;Nguyen, Thi Thu Hoai;Nguyen, Thi Hiep;Nguyen, Tan Dat;Nguyen, Thanh Truc;Ly, Khanh Loan;Tran, Anh Hien;Nguyen, Thi Thanh Ngoc;Vo, Minh Thuy;Ho, Hieu Minh;Dang, Ngoc Thao Nhi;Vo, Van Toi;Nguyen, Dai Hai;Nguyen, Thi Thu Hoai;Nguyen, Thi Hiep;
Journal international journal of polymer science
Year 2019
DOI
10.1155/2019/7382717
URL
https://www.hindawi.com/journals/ijps/2019/7382717/abs/
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