The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa

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2019
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Abstract
Background. Despite the high prevalence of the HIV/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population. Methods. A cross-sectional study was completed in Kinshasa, the Democratic Republic of Congo. HIV-infected children aged between six and 18 years on ARV were consecutively recruited. For each case, two control children (one non-HIV infected child and one HIV-infected antiretroviral therapy-naïve child) were also recruited. Results. 80 HIV-infected on ARV therapy children (group 1), 80 noninfected children (group 2) and 65 HIV-infected antiretroviral therapy-naïve children (group 3) were recruited. The frequency of lipoatrophy was not statistically different between group 1 (16.3%) and group 3 (21.5%). A significantly higher proportion of lipohypertrophy, hypercholesterolemia, and lactic acidosis was noted in children of group 1, compared to the controls (p0.05). Conclusion. Lipohypertrophy, hypercholesterolemia, and lactic acidosis emerge as a frequent metabolic disorders due to ARV therapy.
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kalombayi2019theinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tshamala, Honoré Kalombayi;Aketi, Loukia;Tshibassu, Pierre Manianga;Ekila, Mathilde Bothale;Mafuta, Eric Musalu;Kayembe, Patrick Kalambayi;Aloni, Michel Ntetani;Shiku, Joseph Diayisu;Tshamala, Honoré Kalombayi;Aketi, Loukia;Tshibassu, Pierre Manianga;Ekila, Mathilde Bothale;Mafuta, Eric Musalu;Kayembe, Patrick Kalambayi;Aloni, Michel Ntetani;Shiku, Joseph Diayisu;
Journal international journal of pediatrics
Year 2019
DOI
10.1155/2019/7013758
URL
https://www.hindawi.com/journals/ijpedi/2019/7013758/abs/
Keywords Keywords not found

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