Self-Catalyzed Rapid Synthesis of -Acylated/-Formylated α-Aminoketones and -Hydroxymethylated Formamides from 3-Aryl-2-Azirines and 2-Me/Ph-3-Aryl-2-Azirines.

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ID: 106054
2020
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Abstract
A rapid and effective method has been established for the synthesis of -acylated α-aminoketone derivatives by the reaction of 3-aryl-2-azirines and highly substituted 2-Me/Ph-3-aryl-2-azirines with various carboxylic acids under ambient air within 10 min at room temperature. -Trifluoroacetylated α-aminoketones with different substituents have been reported in the presence of trifluoroacetic acid. This protocol is equally effective to synthesize -formylated α-aminoketone and -hydroxymethylated formamide derivatives.
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de2020selfcatalyzedorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors De, Aramita;Santra, Sougata;Zyryanov, Grigory V;Majee, Adinath;
Journal Organic letters
Year 2020
DOI
10.1021/acs.orglett.0c01206
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Keywords
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